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Viagra treats erectile dysfunction, the inability to achieve and/or maintain an erection of the penis that is adequate for sexual intercourse. Ten to fifteen million men in the United States suffer from ED, and by age 65, up to 25% of men have experienced impotence problems.

In addition to human corpus cavernosum smooth muscle, PDE5 is also found in lower concentrations in other tissues including platelets, vascular and visceral smooth muscle, and skeletal muscle. The inhibition of PDE5 in these tissues by sildenafil may be the basis for the enhanced platelet antiaggregatory activity of nitric oxide Sildenafil Sources observed in vitro, an inhibition of platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo.

Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) buy Cialis 100mg online hepatic isoenzymes. The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further. This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil. Thus, the metabolite is responsible for about 20% of sildenafil's action. Sildenafil is excreted as metabolites predominantly in the feces buying Viagra on line (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose). If taken with a high-fat meal, absorption is reduced; the time taken to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly one-third.

Some common drugs can cause erectile dysfunction, such as those prescribed for depression, heart conditions and blood pressure. However, you should talk to your doctor before you stop or change them. Drinking heavily how many mg of Sildenafil should i take and using illegal drugs can also contribute towards erectile dysfunction in young men.

On average, Viagra becomes effective in just under an hour when you take a tablet on an empty stomach. Viagra can remain effective for between four and six hours. If you take it after a meal that has a high fat content, it may take longer than an hour to become effective.

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A high-fat meal may delay how quickly the drug begins to work.

Sildenafil belongs to a group of medicines that delay the action of enzymes called Viagra Generic Brand phosphodiesterases that can interfere with erectile function. Sildenafil is used to treat men with erectile dysfunction (also called sexual impotence) because it helps to maintain an erection that is produced when a man is sexually excited. Without physical stimulation of the penis, sildenafil will not work to cause an erection. Sildenafil is not indicated for use in women.

It acts by inhibiting cGMP-specific phosphodiesterase type 5 (PDE5), an enzyme that Kamagra and other drugs promotes degradation of cGMP, which regulates blood flow in the penis.

Pharmacists recommend that most patients start with a Viagra dosage of 50mg, administered orally, as and when required. Viagra should be consumed approximately one hour before sex. As a general

rule of thumb, the 50mg Viagra dosage is a guideline for first-time users, and can be increased to 100mg if required or decreased to 25mg, depending on the efficacy of the drug on the individual. Viagra can be taken Sildenafil Sildenafil with food or on an empty stomach, however fatty foods may decrease its effects. Users with moderate hepatic impairment (liver or kidney problems) should take a Viagra dosage of no more than 25mg. Patients on dialysis should completely avoid Viagra and other erectile dysfunction medications.

Viagra (sildenafil) relaxes muscles and increases blood flow to particular areas of the body. Viagra the cost of Cialis is used to treat erectile dysfunction (impotence) in men.

Viagra requires time to be absorbed by the body and become effective. The average recommended time frame for taking the drug is one hour before initiating sexual activity, although depending on an individual's response to the drug, this time can vary from four hours to 30 minutes.

Viagra is a vasodilator, a drug that has the effect of dilating the blood vessels. It works by improving blood circulation to the penis, and by enhancing the effects of nitric oxide, the agent that relaxes the smooth muscle of the penis and regulates blood vessels during sexual stimulation, allowing the penis to become engorged and achieve an erection.

Erectile dysfunction is a condition where the penis does

not harden and expand when a man is sexually excited, or when he cannot keep an erection. When a man is sexually stimulated, his body's normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, sildenafil helps to maintain an erection after the penis is stroked

. Without physical action to the penis, such as that occurring during sexual intercourse, sildenafil will not work to cause an erection.

VIAGRA is rapidly absorbed after oral administration, with a mean absolute bioavailability of 41% (range 25-63%). Its pharmacokinetics are dose-proportional over the recommended dose range. It is eliminated predominantly by hepatic metabolism (mainly cytochrome P450 3A4) and is converted to an active metabolite with properties similar to the parent, sildenafil. The concomitant use of potent cytochrome

P450 3A4 inhibitors (e.g., erythromycin, ketoconazole, itraconazole) as well as the nonspecific CYP inhibitor, cimetidine, Generic Levitra Order is associated with increased plasma levels of sildenafil. Both sildenafil and the metabolite have terminal half lives of about 4 hours.

Viagra's meteoric rise to fame has seen it enter usage as an illicit drug. But, Viagra use in individuals without erectile dysfunction does not seem to have any effect. Although, researchers have noted that there is a significant placebo effect. On a similar note, there is no proven benefit for women taking the drug.

Sildenafil is

used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, sildenafil works by increasing blood flow to the penis to help a man get and keep an erection.

Some people who have yet to order generic Viagra online suspect that they must be too good to be true. At a glance, offering high-quality products at a tiny fraction of normal prices might seem impossible. Yet everyone's expectations for what drug prices should be are based on an industry that is suffused with price gouging. It's important to remember that for almost all pharmaceutical companies, the cost to manufacture their products is a very small fraction of

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A study of African American and Hispanic men published in 2002 reported that Viagra appears to be equally safe and equally effective across different racial and ethnic groups in the United States.